Afghanistan batter Hazratullah Zazai scored 140 runs on fours and sixes in his knock of 162 against Ireland in 2019, which is the most in a T20I innings. The second on the list is former Australia opener Aaron Finch, who scored 128 out of 156 runs on fours and sixes against England in 2013. The third position is held by Aaron Finch too; he scored 124 out of 172 runs on fours and sixes against Zimbabwe in 2018. Check out the list of batters hitting the most runs from fours and sixes in a T20I inning.
| Player | Runs | Balls | 4s | 6s | 4+6 | SR | Team | Opposition | Match Date |
| Hazratullah Zazai | 162* | 62 | 11 | 16 | 140 | 261.29 | Afghanistan | v Ireland | 23-Feb-19 |
| Aaron Finch | 156 | 63 | 11 | 14 | 128 | 247.61 | Australia | v England | 29-Aug-13 |
| Aaron Finch | 172 | 76 | 16 | 10 | 124 | 226.31 | Australia | v Zimbabwe | 03-Jul-18 |
| Zeeshan Kukikhel | 137 | 49 | 7 | 15 | 118 | 279.59 | Hungary | v Austria | 05-Jun-22 |
| Glenn Maxwell | 145* | 65 | 14 | 9 | 110 | 223.07 | Australia | v Sri Lanka | 06-Sep-16 |
| Rohit Sharma | 118 | 43 | 12 | 10 | 108 | 274.41 | India | v Sri Lanka | 22-Dec-17 |
| Johnson Charles | 118 | 46 | 10 | 11 | 106 | 256.52 | West Indies | v South Africa | 26-Mar-23 |
| George Munsey | 127* | 56 | 5 | 14 | 104 | 226.78 | Scotland | v Netherlands | 16-Sep-19 |
| Leslie Dunbar | 117 | 50 | 9 | 11 | 102 | 234 | Serbia | v Bulgaria | 26-Jun-22 |
| K Kadowaki-Fleming | 114 | 46 | 10 | 10 | 100 | 247.82 | Japan | v South Korea | 15-Oct-22 |
